Cerebellum and brain stem volume loss in relapsing remission multiple sclerosis by MRI volumetry: relation to neurological disability score and number of relapses

Abstract Background MRI is the method of choice in diagnosis MS as well monitoring disease activity. volumetry used to assess whole or regional brain volume loss which reflects neurodegenerative aspect and plays an important role all stages disease. The aim this work study evaluation cerebellum stem RRMS patients its correlation with neurological disability score number relapses. Results Volumes brainstem, medulla, pons showed a significant decrease cases compared controls ( p < 0.05). Brainstem had mean 22.17 25.09 cm 3 controls, respectively. However, midbrain no difference between = 0.134). Volume left cerebellar cortex 0.001). It volumes 81.64 92.14 ml respectively, at hemisphere, while right hemisphere were 80.37 91.97 Cerebellar white matter controls. Conclusion Volumetric MR imaging tool for quantifying disease, assesses activity, progression, tissue loss. degree pattern atrophy on images correlate significantly